In the summer of 1979, a group of friends in a small Ohio town witnesses a catastrophic train crash while making a Super 8 movie and soon they suspect that it was not an accident. Shortly after, unusual disappearances and inexplicable events begin to take place in town, and the local deputy tries to uncover the truth, something more terrifying than any of them could have imagined.

Five medical students, obsessed by what lies beyond the confines of life, embark on a daring experiment: by stopping their hearts for short periods, each triggers a near-death experience, giving them a firsthand account of the afterlife. But as their experiments become increasingly dangerous, they are each haunted by the sins of their pasts, brought on by the supernatural consequences of trespassing to the other side.