With the colonization of BrazilÕs Mid-West in the 1950s and the construction of the Transamazônica and other highways in the 1970s, whites began to make large-scale contact with Indians, with disastrous results. Epidemics decimated populations of groups such as the Cinta-Larga, with the deaths amounting in some cases to veritable genocide.

Set in the 1920s. A young English couple, Walter a middle class doctor and Kitty, an upper-class woman, get married for all the wrong reasons and relocate to Shanghai. Kitty falls in love with someone else. When Walter discovers her infidelity, in an act of vengeance, he accepts a job in a remote village in China that is being ravaged by a deadly epidemic. He takes his wife along and their journey brings meaning to their relationship and gives them...