One summer's day, ten-year-old India Opal Buloni goes down to the local supermarket for some groceries - and comes home with a dog. But Winn-Dixie is no ordinary dog. It's because of Winn-Dixie that Opal begins to make friends. And it's because of Winn-Dixie that she finally dares to ask her father about her mother, who left when Opal was three. In fact, as Opal admits, just about everything that happens that summer is because of Winn-Dixie.

Doctor De Soto, a mouse dentist, copes with the toothaches of various animals except those with a taste for mice, until the day a fox comes to him in great pain.

When he finds a lost beagle in the hills behind his West Virginia home, Marty tries to hide it from his family and the dog's real owner, a mean-spirited man known to shoot deer out of season and to mistreat his dogs.

While running away from home and an unwanted marriage, a thirteen- year-old Eskimo girl becomes lost on the North Slope of Alaska and is befriended by a wolf pack.

An old hound that has been chained up at his hateful owner's run-down shack, and two kittens born underneath the house, endure separation, danger, and many other tribulations in their quest to be reunited and free.